Ryan D'Arcy B.Sc, M.Sc, PhD
Associate Professor
Education
B.Sc. (University of Victoria)
M.Sc. (Dalhousie)
PhD (Dalhousie)
Publications
Peer Reviewed Journal Articles
(126 total published works: 44 papers, chapters and patents; and 82 abstracts)
D’Arcy, R.C.N., Bardouille, T., Newman, A.J., McWhinney, S.R., DeBay, Sadler, R.M., Clarke, D.B., & Esser, M.J. (Submitted). Spatiotemporal MEG laterality maps for language: Improved clinical applications in epilepsy.
Gawryluk*, J.R., Mazerolle*, E.L., Beyea, S.D., & D’Arcy, R.C.N. (Submitted). White matter fMRI activation: Linking neuropsychology to advances in brain imaging.
Clarke D.B., D’Arcy, R.C.N., Ghosh Hajra, S. and the GHI-4 Project team collaborators. (Submitted). Virtual reality simulator: Demonstrated use in neurosurgical oncology.
Zhang*, N., Song, X., Zhang, Y., Chen*, W., D’Arcy, R.C.N., Darvesh, S., Fisk, J.D., & Rockwood, K. (2011). An MRI brain atrophy and lesion index to assess the progression of structural changes in Alzheimer’s disease, mild cognitive impairment, and normal aging: A follow-up study. Alzheimer’s and Dementia. Accepted.
Gawryluk*, J.R., Mazerolle*, E.L., Brewer*, K.D., Beyea, S.D., D’Arcy, R.C.N. (2011). Detection of fMRI activation in the internal capsule and functionally-guided DTI tractography. BMC Neuroscience, 12(1), 56.
D’Arcy, R.C.N., Gawryluk*, J.R., Beyea, S.D., Ghosh Hajra, S., Feindel, K.W., Clarke, D.B. (2011). Tracking cognitive changes in new-onset epilepsy: Functional imaging challenges. Epilepsia, 52(s5), 43-46.
Bolster, R.B., D’Arcy, R.C.N., Song, X., Runke*, D., Ryner, L. (2011). Detection vs. location judgments in a hidden pattern task: behavioural and fMRI correlates. Journal of Clinical and Experimental Neuropsychology, 7, 1-11.
Gawryluk*, J.R., D’Arcy, R.C.N., Mazerolle*, E.L., Brewer*, K.D., Beyea, S.D. (2011). Functional mapping in the corpus callosum: A 4T fMRI study of white matter. NeuroImage, 54, 10-15.
D’Arcy, R.C.N., Ghosh-Hajra, S., Liu, C., Sculthorpe, L., & Weaver, D.F. (2011). Towards brain first-aid: A diagnostic device for conscious awareness. IEEE Transactions on Biomedical Engineering. 58(3), 750-754. Early access IEEE Xplore.
Chen*, W., Song, X., Beyea, S.D., D’Arcy, R.C.N., Zhang, Y., & Rockwood, K. (2011). Advances in perfusion magnetic resonance imaging in Alzheimer’s disease. Alzheimer’s and Dementia, 7(2), 185-196. Epub ahead of print.
Chen*, W., Song, X., Zhang, Y., Darvesh, S., Zhang, N., D’Arcy, R.C.N., Black, S., & Rockwood, K. (2010). An MRI-based semiquantitative index for the evaluation of brain atrophy and lesions in Alzheimer’s disease, mild cognitive impairment, and normal aging. Alzheimer's Disease Neuroimaging Initiative. Dementia and Geriatric Cognitive Disorders, 30(2), 121-130.
Versteeg*, V., Marchand, Y., Mazerolle*, E.L., & D’Arcy, R.C.N. (2010). Profiling brain function: Spatiotemporal characterization of normal and abnormal visual evoked potential. Journal of Neuroscience Methods, 190(1), 95-105.
Gawryluk*, J.R., D’Arcy, R.C.N., Connolly, J.F., & Weaver, D.F. (2010). Improving the clinical assessment of consciousness with advances in electrophysiology and neuroimaging techniques. BMC Neurology. 10(1): 11. Top 10 Accessed Article.
Mazerolle*, E.L., Beyea, S.D., Gawryluk*, J.R., Brewer*, K.D., Bowen, C.V., D’Arcy, R.C.N. (2010). Confirming white matter fMRI in the corpus callosum: Co-localization with DTI tractography. NeuroImage, 50: 616-621.
Brewer*, K.D., Rioux*, J.A., D’Arcy, R.C.N., Bowen, C.V., & Beyea, S.D. (2009). Asymmetric spin-echo (ASE) spiral improves BOLD fMRI in Inhomogeneous Regions. NMR in Biomedicine, 22(6), 654-652.
Gawryluk*, J.R., Brewer*, K.D., Beyea, S.D., & D’Arcy, R.C.N. (2009). Optimizing the detection of white matter fMRI using asymmetric spin echo spiral. NeuroImage. 45, 83-88.
Mazerolle*, E.L., D’Arcy, R.C.N. & Beyea, S.D. (2008). Detecting functional magnetic resonance imaging activation in white matter: Interhemispheric transfer across the corpus callosum. BMC Neuroscience, 9: 84. Top 10 accessed, Feature Article.
Hadskis, M., Kenny, N., Downie, J., Schmidt, M., & D’Arcy, R. (2008). The therapeutic misconception: A threat to valid parental consent for pediatric neuroimaging research. Accountability in Research: Policies and Quality Assurance. 15 (3), 133-151.
Mazerolle*, E.L., D’Arcy, R.C.N., Marchand, Y.M., & Bolster, R.B. (2007). ERP assessment of functional status of the temporal lobe: Examining spatiotemporal correlates of object recognition. International Journal of Psychophysiology, 66, 81-92.
Brewer*, K.D., Osberg*, B.L., Rioux*, J.A., D’Arcy, R.C.N., Stroink, G., Beyea, S.D. (2007). Is 4.0 Tesla MRI advantageous for current source localization of weak magnetic fields? International Congress Series: Biomagnetism, 1300, 565-569.
Downie, J., Schmidt, M.H., Kenny, N., D’Arcy, R.C.N., Hadskis, M., & Marshall*, J. (2007). Paediatric MRI research ethics: The priority issues. Journal of Bioethical Inquiry, 4, 85-91.
D’Arcy, R.C.N., Bolster, R.B., Ryner, L., Mazerolle*, E.L., Grant*, J., & Song, X. (2007). A site directed fMRI approach for evaluating functional status in the anterolateral temporal lobes. Neuroscience Research, 57(1), 120-128.
Connolly, J.F., Marchand, Y., Major, A., & D’Arcy, R.C.N. (2006). Event-related brain potentials as a measure of performance on WISC-III and WAIS-R NI Similarities sub-tests. Journal of Clinical and Experimental Neuropsychology, 28(8), 1327-1345.
D’Arcy, R.C.N., Hamilton*, A., Jarmasz, M., Sullivan*, S., & Stroink, G. (2006). Exploratory data analysis reveals visuovisual interhemispheric transfer in fMRI. Magnetic Resonance in Medicine, 55, 952-958.
D’Arcy, R.C.N., Service, E., Connolly, J.F., & Hawco*, C.S. (2005). The influences of increased working memory load on semantic neural systems: A high-resolution event-related brain potential study. Cognitive Brain Research, 22 (2), 177-191.
D’Arcy, R.C.N., Ryner, L., Richter, W., Service, E., & Connolly, J.F. (2004). The fan effect in fMRI: Left hemisphere specialization in verbal working memory. NeuroReport, 15 (12) 1851-1855.
D’Arcy, R.C.N., Connolly, J.F., Service, E., Hawco*, C.S., & Houlihan, M.E. (2004).Separating phonological and semantic processing in auditory sentence processing: A high-resolution event-related brain potential study. Human Brain Mapping, 22 (1), 40-51.
D’Arcy, R.C.N., Marchand, Y., Eskes, G.A., Harrison, E.R, Major, A., Phillips, S.J., & Connolly, J.F. (2003). Electrophysiological assessment of language function following stroke. Clinical Neurophysiology, 114 (4), 662-672.
Marchand, Y., D’Arcy, R.C.N., & Connolly, J.F. (2002). Linking neurophysiological and neuropsychological measures for aphasia assessment. Clinical Neurophysiology, 113(11), 1715-1722. (Editorial).
Connolly, J.F., Service, E., D’Arcy, R.C.N., Kujala, A., & Alho, A. (2001). Phonological aspects of word recognition as revealed by high-resolution spatio-temporal brain mapping. NeuroReport, 12(2), 237-243.
D’Arcy, R.C.N., Connolly, J.F., & Eskes, G.A. (2000). Evaluation of reading comprehension with neuropsychological and event-related brain potential (ERP) methods. Journal of the International Neuropsychological Society, 6, 552-563.
D’Arcy, R.C.N., Connolly, J.F., & Crocker*, S.F. (2000). Latency shifts in the N2b component track phonological deviations in spoken words. Clinical Neurophysiology, 111(1), 40-44.
Connolly, J.F., D’Arcy, R.C.N., Newman R.L. & Kemps*, R. (2000). The application of cognitive event-related brain potentials in language-impaired individuals: Review and case studies. Invited review. International Journal of Psychophysiology, 38(1), 55-70.
Connolly, J.F., & D’Arcy, R.C.N. (2000). Innovations in neuropsychological assessment using event-related brain potentials. Invited review. International Journal of Psychophysiology, 37(1), 31-47.
D’Arcy, R.C.N., & McGlone, J. (2000). Profound amnesia does not impair performance on the 36-item Digit Memory Test - a test of malingered memory deficits. Brain and Cognition, 44(1), 54-58.
D’Arcy, R.C.N., & Connolly, J.F. (1999). An event-related brain potential study of receptive speech comprehension using a modified Token Test. Neuropsychologia, 37(13), 1477-1489.
Connolly, J.F., Major, A.M., Allen, S.L., & D’Arcy, R.C.N. (1999). Performance on WISC-III and WAIS-R NI vocabulary subtests assessed with event-related brain potentials: An innovative method of assessment. Journal of Clinical and Experimental Neuropsychology. 21(4), 444-464.
Book Chapters
Zhang*, N., Song, X., Zhang, Y., Chen*, W., D’Arcy, R.C.N., Darvesh, S., Fisk, J.D., & Rockwood, K. (2011). An MRI brain atrophy and lesion index to assess the progression of structural changes in Alzheimer’s disease, mild cognitive impairment, and normal aging: A follow-up study. Handbook of Imaging the Alzheimer’s Brain. Volume 2 Advances in Alzheimer’s Disease. J.W. Ashford, A. Rosen, M. Adamson, P. Bayley,
O. Sabri, A. Furst, S.E. Black and M. Weiner (Eds.) IOS Press.
Gawryluk*, J.R. & D’Arcy, R.C.N. (2010). Electroencephalography: Basic concepts and brain applications. Handbook of Physics in Medicine and Biology. R. Splinter (Ed.). Taylor and Francis.
Mateer C.A., & D’Arcy, R.C.N. (2000). Current concepts in assessment and management. S. Raskin & C. Mateer (Eds.). Neuropsychological Management of Mild Traumatic Brain Injury. New York: Oxford University Press.
Presentations
D’Arcy, R.C.N., Bardouille, T., McWhinney*, S.R., Newman, A.J. & Esser, M.J.(2011) Biomagnetic laterality mapping of brain function in epilepsy. Bioelectromagnetics Society, Halifax.
D’Arcy, R.C.N., Sculthorpe, L.D., Liu, C., & Ghosh-Hajra, S. (2011). “Are you in there?” - A comparison of brain-based evaluation of conscious awareness and the Glasgow Coma Scale. Society for Psychophysiological Research, Boston.
Sculthorpe L.D., D’Arcy, R.C.N., Wei, C., Ghosh-Hajra, S., & Liu, C. (2011). Assessing brain function when every second counts. Society for Psychophysiological Research, Boston.
Clarke, D.B., D’Arcy, R.C.N., Brooks, R., Jiang, D., Ayres, F., Ghosh Hajra, S., Stevens*, T., Hovdebo, J., Borgeat, L., Massicotte, P., Poirier, G., Mora, V., Marcotte, J.P., Laroche, D., Delorme, S., Diraddo, R. (2010). World’s first patient-specific open neurosurgery rehearsal. Canadian Neurological Science Federation. (Quebec, oral presentation).
Mazerolle*, E.L. Gawryluk*, J.R., Brewer, K.D., Beyea, S.D., & D’Arcy, R.C.N. (2010). White matter fMRI activation in the internal capsule. Organization of Human Brain Mapping (Barcelona, oral presentation).
Dillen*, K., Gawryluk*, J.R., Stevens*, T., Bowen, C.V., Beyea, S.D., Liu C., Newman, A., Stroink G., Eskes, G.A., Schmidt M.H., Clarke, D.B., & D’Arcy, R.C.N. (2009). Characterizing the effects of magnetic field strength on specificity in functional MRI: Application in pre-surgical mapping. Canadian Neurological Sciences Foundation. (oral presentation).
Stevens*, T.M., D’Arcy, R.C.N., Clarke, D.B., & Beyea, S. (2009). Mapping the spatial relationship between fMRI and intraoperative electrocortical stimulation data for improved efficacy of surgical brain tumor resection. Canadian Neurological Sciences Foundation. (oral presentation).
D’Arcy, R.C.N. & Newman A. (2009). Clinical neuroscience and the emergence of functional diagnostic imaging. Canadian Neuroscience Meeting. Symposium Chair.
D’Arcy, R.C.N. (2009). The emergence of functional imaging as standard of care for neurosurgical planning for brain tumours and epilepsy. Canadian Neuroscience Meeting. (oral presentation).
Gawryluk*, J.R., Connolly, J.F., Weaver, D.F., & D’Arcy, R.C.N. (2008). Improving the clinical assessment of consciousness: A review of advances in functional imaging. Julian Jaynes Conference on Consciousness. (Charlottetown, Canada).
Marchand, Y., Versteeg*, V., D’Arcy, R.C.N., Mazerolle*, E.L., Stroink, G. (2008). A similarity ranking method for evaluating individual EEG/MEG source localization maps in both sensory and cognitive tasks. International Conference on Biomagnetism (Sapporo, Japan).
Song, X., D'Arcy, R.C.N., Fisk, J., Darvesh, S., Beyea, S., Rockwood K. (2008). Enhanced DLPFC activation in mild Alzheimer's disease during encoding and retrieval: Preliminary results from a 4T fMRI study. International Conference on Alzheimer's Disease 2008 (and Alzheimer Neuroimaging Consortium).
Song, X., D'Arcy, R.C.N., Major, A., Fisk, J., Darvesh, S., Marshall, J., Rioux*, J., Bowen, C., Beyea, S., Rockwood K. (2008). Activation of DLPFC during rest in early Alzheimer's disease: A
preliminary study using 4 Tesla fMRI. International Conference on Alzheimer's Disease 2008 (and Alzheimer Neuroimaging Consortium).
Mazerolle*, E.L., Song, X., Brewer*, K.D., Beyea, S.D., & D’Arcy, R.C.N. (2008). Functional MRI in white matter: Experimental evidence at 4-T. Proceedings of the International Society for Magnetic Resonance in Medicine 16. (2008). (Toronto, oral presentation).
Song, X., D’Arcy, R.C.N., & Rockwood, K. (2007). Does the brain of older adults work harder than that of younger adults? - Preliminary results of a functional magnetic resonance imaging study at 4 Tesla. The 11th International Congress of the International Federation of Psychiatric Epidemiology.
D’Arcy, R.C.N., Marchand, Y., Connolly, J.F. (2006). Consciousness at the electrical level: Insights from brain waves and brain injury. Julian Jaynes Conference on Consciousness. (Charlottetown, Canada, Symposium speaker).
Grants & Awards
Grants
Atlantic Canada Opportunities Agency
Atlantic Innovation Fund (2010-2012)
Elekta Neuromag, Canada: The development of a translational imaging cluster in Halifax
IWK Health Centre
PIs: D’Arcy, R.C.N., McGrath, P., Ahonen, A., Weaver, D.F.
CIs: Stroink, G., Beyea, S.D., Newman, A., Clarke, D.C.
Value: $1 800 000
Business Development Program (2011)
Small animal PET/CT
IWK Health Centre
PIs: D’Arcy, R.C.N., McGrath, P., & Bowen, C.V., Ross, A., Burrell, S., & Barnes, D.
Value: $430 000
Business Development Program (2009)
Laboratory for Clinical Magnetoencephalography (MEG)
IWK Health Centre
PIs: D’Arcy, R.C.N., McGrath, P., & Weaver, D.F.
Value: $500 000
Atlantic Initiative
NRC cluster renewal (2005)
Institute for Biodiagnostics (Atlantic)
Business Case: D’Arcy R.C.N. and Smith I.C.P.
Value: $8 200 000 (five years)
Canadian Foundation for Innovation (CFI)
Research Hospital Fund (2004)
Biomedical MRI Research Laboratory (BMRL)
PIs: Weaver, D. & McMaster C.
CIs: D’Arcy, R.C.N., Beyea, S.D., Leslie, R., Walter, J. Schmidt, M., & Bolinger, L.
Value: $909 000
Canadian Institutes for Health Research(CIHR)
China-Canada Joint Health Research Initiative (2011-2014)
PI: D’Arcy, R.C.N.
CIs: Song, X., Beyea, S.D.
Title: Functional neuroimaging of white matter integrity in cognitive dysfunction: Linking neuroscience research with clinical evaluation
Value: $149 400 (three years)
Neuroethics New Emerging Teams Grant Program (2004-2009)
PI: Downie, J.
CIs: Bolinger, L, Kenny, N.P., Magwood, B.D., Malisza, K.L., Yu, D.C., Hadskis, M., Martin, T., & D’Arcy, R.C.N.
Title: Neuroimaging ethics: From theory to practice.
Value: $1 485 000 (five years)
Equipment Grant (2002)
PI: Bolster, B.
CIs: D’Arcy, R.C.N., McIntyre, M., Clarke, J., & Ryner, L.
Title: Equipment for Cognitive Neuroscience and Functional Neuroimaging
Value: $6 000
Capital Health
Dalhousie Medical Research (2009)
Equipment Grant
PIs: Schmidt, M.H. & D’Arcy, R.C.N.
CIs: Clarke, D., & Newman, A.
Characterizing the effects of field strength on specificity in functional MRI: Application in pre-surgical mapping.
Value: $11 000
Research Grant (2008)
PI: Song, X.
CIs: Rockwood, K. D’Arcy, R.C.N., & Beyea, S.D.
Title: Investigation of cerebral perfusion changes related to the neurocompensatory in early Alzheimer’s disease: A pilot MRI study at 4 Tesla.
Value: $15 000
Radiology Research Grant (2009)
PIs: Beyea, S.D. D’Arcy, R.C.N.
Title: Functional MRI and presurgical mapping of brain tumours
Value: $10 000
Radiology Research Grant (2006)
PI: Beyea, S.D.
CIs: D’Arcy, R.C.N. et al.
Title: Improved functional imaging and multimodal integration at 4T. Part 1: fMRI experiments.
Value: $10 000
Research Grant (2006)
PI: Eskes, G. CIs: Christie, J., Clarke, D., D’Arcy, R.C.N., Hill, R., McAndrews, M.P., Newman, A., Schmidt, M., & Stroink, G.
Title: Development of a presurgical functional MRI protocol for mapping sensorimotor and language regions: A pilot study.
Value: $15 000
DFAIT: Foreign Affairs and International Trade Canada
Going Global Innovation (2011)
PIs: Goldwitz, D., D’Arcy, R.C.N., & Hofstein, R.
Title: Canada-Israel Technology Innovation Summit 2011 - Brain Research Roundtable and Related Meetings
Value: $30 000
North America Platform Program: Canada-USA (2011)
PIs: D’Arcy, R.C.N., Lalanne, D., Weaver, D.F., Barden, C.J., & Watlington, T.
Title: Neurotrauma – Point-of-care technology program
Value: $25 000
Early Stage Commercialization Fund
Medical Devices (2010)
PIs: D’Arcy, R.C.N., Weaver, D.F., Barden, C.J.
Title: Prototype development for Halifax Consciousness Scanner
Value: $50 000
IWK Health Research
Operating Grant (2009)
PI: D’Arcy. R.C.N.
CIs: Esser, M., Newman, A., Khan, N.
Title: Evaluating language and memory lateralization for surgical treatment in epilepsy: A multimodal functional MRI and magnetoencephalography study.
Value: $15 000
NRC Genomics and Health Initiative (2008-2010)
PIs: DiRaddo, R., Laroche, D., Delorme, S., Hétu, J.F., Tomanek, B., D’Arcy, R.C.N., Alexander, M., & Godin, G.
Title: Patient-specific virtual reality systems for surgical oncology – Phase 2.
Value: $1 700 000
PIs: DiRaddo, R., Laroche, D., Delorme, S., Hétu, J.F., Tomanek, B., D’Arcy, R.C.N., Alexander, M., & Godin, G.
Title: Patient-specific virtual reality systems for surgical oncology – Phase 1.
Value: $4 980 000
Natural Sciences and Engineering Research Council (NSERC)
CREATE Grant (2011-2015)
PI: Newman, A.J.
CIs: Bance, M., D’Arcy, R.C.N.
Title: RADIANT Training for neurotechnologies
Value: $1 650 000
Discovery Grant (2009-2014)
PI: D’Arcy, R.C.N.
Title: Multimodal imaging of distributed neural systems in cognition
Value: $144 000 (five years)
Discovery Grant (2004-2009)
PI: D’Arcy, R.C.N.
Title: Integrating electrophysiological and hemodynamic activation in human cognition
Value: $100 000 (five years)
Nova Scotia Health Research Foundation (NSHRF)
Capacity Grant (2008-2009)
PIs: Tibbo, P.
CI:Bernier, D., Song, X., Beyea, S., O’Neill, B., Delva, N., & D’Arcy, R.C.N.
Title: Development and preliminary testing of in vivo localized proton magnetic resonance spectroscopy at 4 Tesla.
Value: $15 000
Health Research Grant (2006-2009)
PI: Song, X.
CIs: Rockwood, K. D’Arcy, R.C.N., & Fisk, J.
Title: Functional and spectroscopic correlates of neurocompensation in Alzheimer’s disease.
Value: $140 000 (three years)
Awards
Public Service Award of Excellence (2011)
Neurosurgical Simulator
Ottawa, Canada
NRC Outstanding Achievement Award (2010)
Public Awareness, Neurosurgical Simulator
Ottawa, Canada
NRC Outstanding Achievement Award (2010)
Community Involvement and Capacity Building
Halifax Life Sciences cluster
Ottawa, Canada
Award of Excellence for Clinical Research (2010)
Dalhousie Medical Research Foundation
Halifax, Nova Scotia
IWK Research Award (2009)
An individual, team or organization whose direct or indirect contribution to the IWK children’s and women’s health is outstanding.
IWK Health Centre, Halifax, Nova Scotia.
Discovery Award, Emerging Professional of Distinction (2008)
In recognition of intellectual achievement, excellence, and the potential for ongoing growth and development in a science and technology.
Discovery Centre, Halifax, Nova Scotia
Discovery Award, Emerging Professional (2007)
Outstanding Contribution in Science and Technology
Halifax, Nova Scotia
Sites of Interest
Personal Website
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rdarcy@dal.ca
(T) (902) 473-1868
(F) (902) 473-1851 |
HALIFAX, NOVA SCOTIA | CANADA
